PUBLICACIONES

2018
Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis. Medinas DB.Rozas P.Martínez Traub F.Woehlbier U.Brown RH.Bosco DA. and Hetz C., 
The effects of a relaxation program featuring aquatic therapy and autogenic training among people with cervical dystonia (a pilot study). Useros-Olmo I., Martínez-Pernía D. and Huepe D., Physiother Theory Pract., 2018, doi: 10.1080/09593985.2018.1488319.
From Snapshots to Movies: The Association Between Retirement Sequences and Aging Trajectories in Limitations to Perform Activities of Daily Living. Azar A., Staudinger UM., Slachevsky A., Madero-Cabib I. and Calvo E., J Aging Health., 2018, doi: 10.1177/0898264318782096.
Structural Anatomical Investigation of Long-Term Memory Deficit in Behavioral Frontotemporal Dementia. Bertoux M., Flanagan EC., Hobbs M., Ruiz-Tagle A., Delgado C., Miranda M., Ibáñez A., Slachevsky A. and Hornberger M., J Alzheimers Dis., 2018, 62(4): 1887-1900.
Endoplasmic Reticulum stress signaling and the pathogenesis of Non-Alcoholic Fatty Liver Disease. Lebeaupin C., Vallée D., Hazari Y., Hetz C., Chevet E., Bailly-Maitre B., J Hepatol., 2018, pii: S0168-8278(18)32161-5.
ER stress sensing mechanism: Putting off the brake on UPR transducers. Rojas-Rivera D., Rodriguez DA., Sepulveda D. and Hetz C., Oncotarget., 2018, 9(28): 19461-19462.
Gene Therapy Strategies to Restore ER Proteostasis in Disease. Valenzuela V., Jackson KL., Sardi SP. and Hetz C., Mol Ther., 2018, 26(6): 1404-1413.
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Galluzzi L., Vitale I., Aaronson SA, Abrams JM., Adam D., Agostinis P., Alnemri ES., Altucci L., Amelio I., Andrews DW., Annicchiarico-Petruzzelli M., Antonov AV., Arama E., Baehrecke EH., Barlev NA., Hetz C et al., Cell Death Differ., 2018, 25(3): 486-541.
IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A. Urra H., Henriquez DR., Cánovas J., Villarroel-Campos D., Carreras-Sureda A., Pulgar E., Molina E., Hazari YM., Limia CM., Alvarez-Rojas S., Figueroa R., Vidal RL., Rodriguez DA., Rivera CA., Court FA., Couve A., Qi L., Chevet E., Akai R., Iwawaki T., Concha ML., Glavic Á., Gonzalez-Billault C., Hetz C., Nat Cell Biol., 2018, doi: 10.1038/s41556-018-0141-0.
Editorial: From Ecology to Brain Development: Bridging Separate Evolutionary Paradigms. Aboitiz F., Concha M.L. and González-Billault C. and Mpodozis J., Front Neurosci., 2018, 12:447.
Dementia in Latin America: Assessing the present and envisioning the future. Parra M.A., Baez S., Allegri R., Nitrini R., Lopera F., Slachevsky A., Custodio N., Lira D., Piguet O., Kumfor F., Huepe D., Cogram P., Bak T., Manes F. and Ibanez A., Neurology., 2018, 90(5): 222-231.
Neuroanatomical Comparison of the “Word” and “Picture” Versions of the Free and Cued Selective Reminding Test in Alzheimer’s Disease. Slachevsky A., Barraza P., Hornberger M., Muñoz-Neira C., Flanagan E., Henríquez F., Bravo E., Farías M. and Delgado C., J Alzheimers Dis., 2018, 61(2): 589-600.
In Vitro Analysis of the Role of Schwann Cells on Axonal Degeneration and Regeneration Using Sensory Neurons from Dorsal Root Ganglia. López-Leal R., Diaz P. and Court F.A., Methods Mol Biol., 2018,1739: 255-267.
Purification of Exosomes from Primary Schwann Cells, RNA Extraction, and Next-Generation Sequencing of Exosomal RNAs. De Gregorio C., Díaz P., López-Leal R., Manque P. and Court F.A., Methods Mol Biol., 2018, 1739: 299-315.
Teased Fiber Preparation of Myelinated Nerve Fibers from Peripheral Nerves for Vital Dye Staining and Immunofluorescence Analysis. Catenaccio A. and Court F.A., Methods Mol Biol., 2018, 1739: 329-337.
In Vitro-Generated Tc17 Cells Present a Memory Phenotype and Serve As a Reservoir of Tc1 Cells In Vivo. Flores-Santibáñez F., Cuadra B., Fernández D., Rosemblatt M.V., Núñez S., Cruz P., Gálvez-Cancino F., Cárdenas JC., Lladser A., Rosemblatt M., Bono M.R. and Sauma D., Front Immunol., 2018, 9: 209.
Genome-wide circulating microRNA expression profiling reveals potential biomarkers for amyotrophic lateral sclerosis. Matamala J.M., Arias-Carrasco R., Sanchez C., Uhrig M., Bargsted L., Matus S., Maracaja-Coutinho V., Abarzua S., van Zundert B., Verdugo R., Manque P. and Hetz C., Neurobiol Aging., 2018, 64: 123-138.
Unraveling the role of motoneuron autophagy in ALS. Valenzuela V., Nassif M. and Hetz C., Autophagy., 2018, 1-5.
Homeostatic interplay between FoxO proteins and ER proteostasis in cancer and other diseases. González-Quiroz M., Urra H., Limia C.M. and Hetz C., Semin Cancer Biol., 2018, pii: S1044-579X(17)30207-9.
Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of  Parkinson’s disease. Mercado G., Castillo V., Soto P., López N., Axten J.M., Sardi S.P., Hoozemans J.J.M. and Hetz C., Neurobiol Dis., 2018, 112: 136-148.
Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α. Sepulveda D., Rojas-Rivera D., Rodríguez D.A., Groenendyk J., Köhler A., Lebeaupin C., Ito S., Urra H., Carreras-Sureda A., Hazari Y., Vasseur-Cognet M., Ali M.M.U., Chevet E., Campos G., Godoy P., Vaisar T., Bailly-Maitre B., Nagata K., Michalak M., Sierralta J. and Hetz C., Mol Cell., 2018, 69(2):v238-252.
Dual IRE1 RNase functions dictate glioblastoma development. Lhomond S.Avril T.Dejeans N.Voutetakis K.Doultsinos D.McMahon M.Pineau R.Obacz J.Papadodima O.Jouan F.Bourien H.Logotheti M.Jégou G.Pallares‐Lupon N.Schmit K.Le Reste PJ.Etcheverry A.Mosser J.Barroso K.Vauléon E.Maurel M.Samali A.Patterson JB.Pluquet O.Hetz C.Quillien V.Chatziioannou A. and Chevet E., EMBO Mol Med., 2018, pii: e7929.
(off)Targeting UPR signaling: the race toward intervening ER proteostasis. Pérez-Arancibia R., Rivas A. and Hetz C., Expert Opin Ther Targets, 2018, 22(2): 97-100.
Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer’s disease. Gerakis Y. and Hetz C., FEBS J., 2018, 285(6): 995-1011.
The Unfolded Protein Response and Cell Fate Control. Hetz C. and Papa F.R., Mol Cell., 2018, 69(2): 169-181.
TNF-α Increases Production of Reactive Oxygen Species through Cdk5 Activation in Nociceptive Neurons. Sandoval R., Lazcano P., Ferrari F., Pinto-Pardo N., González-Billault C. and Utreras E., Front Physiol., 2018, 9: 65. 
Crosstalk between Rac1-mediated actin regulation and ROS production. Acevedo A. and González-Billault C., Free Radic Biol Med., 2018, 116: 101-113.
Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α. Sepulveda D., Rojas-Rivera D., Rodríguez D.A., Groenendyk J., Köhler A., Lebeaupin C., Ito S., Urra H., Carreras-Sureda A., Hazari Y., Vasseur-Cognet M.,  Ali M.M.U., Chevet E., Campos G., Godoy P., Vaisar T, Bailly-Maitre B., Nagata K., Michalak M., Sierralta J. and Hetz C., Mol. Cell., 69(2): 238–252.
2017
First symptoms and neurocognitive correlates of behavioral variant frontotemporal dementia. Santamaría-García H., Reyes P., Baéz S., García A., Martinez A., Santacruz J.M., Slachevsky A., Sigman M., Matallana D. and Ibañez A.Journal of Alzheimer’s Disease, 2017, 54(3): 957-970.
Your perspective and my benefit: multiple lesion models of self-other integration strategies during social bargaining. Melloni M., Billete P., Baez S., Hesse E., de la Fuente L., Forno G., Birba A., García Cordero I.,  Serrano C., Plastino A., Slachevsky A., Huepe D.,  Sigman M., Manes F., García A.M. and Ibáñez A.Brain., 2017, 139(11): 3022-3040.
Geographical variation in dementia mortality in Italy, New Zealand, and Chile: the impact of latitude, vitamin D, and air pollution. Russ T.C., Murianni L., Icaza G., Slachevsky A. and Starr J.M.Dement Geriatr Cogn Disord., 2017, 42(1-2): 31-41.
So close yet so far: executive contribution to memory processing in behavioural variant frontotemporal dementia. Bertoux M., Ramanan S., Slachevsky A., Wong S., Henriquez F., Musa G., Dubois B., Bottlaender M., Sarazin M. and Hornberger M.Journal of Alzheimer’s Disease, 2017, 54(3): 1005-1014.
Tau Platelets correlates with regional brain atrophy in patients with Alzheimer’s disease. Slachevsky A., Guzmán-Martínez L., Delgado C., Reyes P., Farías G.A., Muñoz C., Bravo E., Farías M., Flores F., Garrido C., Becker J.T., López O.L. and Maccioni R.B.J. Alzheimers Dis., 2017, 55(4): 1595-1603. 
Cuestionario de actividades de la vida diaria (T-ADLQ): utilidad en pacientes con accidente cerebrovascular menor. Idiáquez J., Torres F., Madrid E., Vega J. and  Slachevsky A., Rev. méd. Chile, 2017, 145(2): 188-193.
Neuroanatomical comparison of the “Word” and “Picture” versions of the Free and Cued Selective Reminding Test in Alzheimer’s disease. Short title: Neuroanatomical correlates of the Free and Cued Selective Reminding Test in Alzheimer’s disease. Slachevsky A., Barraza P., Hornberger M., Muñoz-Neira C., Flanagan E., Henriquez F., Bravo E., Farias M. and Delgado C.Journal of Alzheimer’s Disease, 2017.
The interplay between sharing behavior and beliefs about others in children during dictator games. Santamaría-García H., González-Gadea M.L., Di Tella R., Ibáñez A. and Sigman M.J Exp Child Psychol., 2017, 166:451-464.
A lesion model of envy and Schadenfreude: legal, deservingness and moral dimensions as revealed by neurodegeneration. Santamaría-García H., Baez S., Reyes P., Santamaría-García J., Santacruz-Escudero J., Matallana D., Arévalo A., Sigman M., García A.M. and Ibáñez A.Brain, 2017, 140(12): 3357–3377.
How Empathic are War Veterans? An Examination of the Psychological Impacts of Combat Exposure. Trujillo S., Trujillo N., Ugarriza J.E., Uribe L., Pineda D., Aguirre D., Ibañez A., Decety J. and Garcia-Barrera M.A.Journal of Peace Psychology, 23(4), 422-426.
Empathy for others’ suffering and its mediators in mental health professionals. Santamaría-García H., Baez S., García A.M., Flichtentrei D., Prats M., Mastandueno R., Sigman M., Matallana D., Cetkovich M. and Ibáñez A.Scientific Reports, 2017, 7
Men, women…who cares? A population-based study on sex differences and gender roles in empathy and moral cognition. Baez S., Flichtentrei D., Prats M., Mastandueno R., García A.M., Cetkovich M. and Ibáñez A.PLoS One., 2017, 12(6): e0179336.
Atypical Modulations of N170 Component during Emotional Processing and Their Links to Social Behaviors in Ex-combatants. Trujillo S.P., Valencia S., Trujillo N., Ugarriza J.E., Rodríguez M.V., Rendón J., Pineda D.A., López J.D., Ibañez A. and Parra M.A.Front Hum Neurosci., 2017, 11: 244.
Time-order-errors and duration ranges in the Episodic Temporal Generalization task. Mikulan E., Bruzzone M., Serodio M., Sigman M., Bekinschtein T., García A.M., Sedeño L. and Ibáñez A.Sci Rep., 2017, 7(1): 2643.
Outcome-oriented moral evaluation in terrorists. Baez S., Herrera E., García A.M., Manes F., Young L. and Ibáñez A.Nature Human Behaviour, 2017.
Decision-making interventions to stop the global atrial fibrillation-related stroke tsunami. Cerasuolo J.O., Montero-Odasso M., Ibañez A., Doocy S., Lip G.Y. and Sposato L.A.Int J Stroke., 2017, 12(3): 222-228.
The inner world of overactive monitoring: neural markers of interoception in obsessive-compulsive disorder. Yoris A., García A.M., Traiber L., Santamaría-García H., Martorell M., Alifano F., Kichic R., Moser J.S., Cetkovich M., Manes F., Ibáñez A., Sedeño L.Psychol Med., 2017, 47(11): 1957-1970.
Locating Temporal Functional Dynamics of Visual Short-Term Memory Binding using Graph Modular Dirichlet Energy. Smith K., Ricaud B., Shahid N., Rhodes S., Starr J., Ibanez A., Parra M., Escudero J. and Vandergheynst P.Sci Rep., 2017, 7: 42013.
Rule reactivation and capture errors in goal directed behaviour. Roca M., García M., Torres Ardilla J., González Gadea M.L., Torralva T., Ferrari J., Ibáñez A., Manes F. and Duncan J.Cortex., 2017.
An unaware agenda: interictal consciousness impairments in epileptic patients. Moguilner S., García A.M., Mikulan E., García M.dC., Vaucheret E., Amarillo Y., Bekinschtein T. and Ibáñez A.Neurosci. Conscious., 2017.
Methotrexate pharmacogenetics in Uruguayan adults with hematological malignant diseases. Giletti A., Vital M., Lorenzo M., Cardozo P., Borelli G., Gabus R., Martínez L., Díaz L., Assar R., Rodriguez M.N. and Esperón P., Eur. J. Pharm. Sci., 2017, 109: 480-485.
Genetic Diversity and Virulence Determinants of Escherichia coli Strains Isolated from Patients with Crohn’s Disease in Spain and Chile. Céspedes S., Saitz W., Del Canto F., De la Fuente M., Quera R., Hermoso M., Muñoz R., Ginard D., Khorrami S., Giron J., Assar R., Rosselló-Mora R. and Vidal R.M.Front Microbiol., 2017, 8: 1-14.
Leader Cells Define Directionality of Trunk, but Not Cranial, Neural Crest Cell Migration. Richardson J., Gauert A., Briones Montecinos L., Fanlo L., Alhashem Z.M., Assar R., Marti E., Kabla A., HŠrtel S. and Linker C.Cell Rep., 2016, 15(9): 2076-2088.
Argentinian/Chilean validation of the Spanish-language version of Addenbrooke’s Cognitive Examination III for diagnosing dementia. Bruno D., Slachevsky A., Fiorentino N., Rueda D.S., Bruno G., Tagle A.R., Olavarria L., Flores P., Lillo P., Roca M. and Torralva T.Neurologia., 2017, 3822.
Proteostasis disturbance in amyotrophic lateral sclerosis. Medinas D.B., Valenzuela V. and Hetz C.Hum Mol Genet., 2017, 26(R2): R91-R104.
Prion Function and Pathophysiology in Non-Mammalian Models. Guerrero N., Meynard M., Borgonovo J., Palma K., L. Concha M. and Hetz C., Curr Mol Med., 2017; 17(1): 13-23.
Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration. Catenaccio A., Llavero Hurtado M., Diaz P., Lamont D.J., Wishart T.M. and Court F.A., Cell Death & Disease, 2017,  8: 3166.
Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model. Bargsted L., Medinas D.B., Martínez Traub F., Rozas P., Muñoz N., Nassif M., Jerez C., Catenaccio A., Court F.A., Hetz C. and Matus S., Scientific Reports, 2017, 7(1): 14266.
Herpes Simplex Virus Type 1 Neuronal Infection Perturbs Golgi Apparatus Integrity through Activation of Src Tyrosine Kinase and Dyn-2 GTPase. Martin C., Leyton L., Hott M., Arancibia Y., Spichiger C., McNiven M.A., Court F.A., Concha M.I., Burgos P.V. and Otth C., Front. Cell. Infect. Microbiol., 2017.
Endoplasmic Reticulum-Mitochondria Calcium Communication and the Regulation of Mitochondrial Metabolism in Cancer: A Novel Potential Target. Bustos G., Cruz P., Lovy A. and Cárdenas C.,  Front. Oncol., 2017, 7: 199.
ER Stress and Neurodegenerative Disease: A Cause or Effect Relationship?. Cabral-Miranda F. and Hetz C.,  Curr. Top Microbiol. Immunol., 2017, .
From birth to death: A role for reactive oxygen species in neuronal development. Wilson C., Muñoz-Palma E. and González-Billault C.,  Semin. Cell. Dev. Biol., 2017, .
Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders. Salvadores N., Sanhueza M., Manque P. and Court F.A.,  Front. Neurosci., 2017, 11: .
Parkinson’s disease compromises the appraisal of action meanings evoked by naturalistic texts. García A.M., Bocanegra Y., Herrera E., Moreno L., Carmona J., Baena A., Lopera F., Pineda D., Melloni M., Legaz A., Muñoz E., Sedeño L., Baez S. and Ibáñez A.,  Cortex., 2017.
Corticostriatal signatures of schadenfreude: evidence from Huntington’s disease. Baez S., Pino M., Berrío M., Santamaría-García H., Sedeño L., García A.M., Fittipaldi S. and Ibáñez A.,  J. Neurol. Neurosurg. Psychiatry., 2017, 316055.
Attention, in and Out: Scalp-Level and Intracranial EEG Correlates of Interoception and Exteroception. García-Cordero I., Esteves S., Mikulan E.P., Hesse E., Baglivo F.H., Silva W., García M.D.C., Vaucheret E., Ciraolo C., García H.S., Adol F., Pietto M., Herrera E., Legaz A., Manes F., García A.M., Sigman M., Bekinschtein T.A., Ibáñez A. and Sedeño L.,  Front. Neurosci., 2017, 11: 411.
Tackling variability: A multicenter study to provide a gold-standard network approach for frontotemporal dementia. Sedeño L., Piguet O., Abrevaya S., Desmaras H., García-Cordero I., Baez S., Alethia de la Fuente L., Reyes P., Tu S., Moguilner S., Lori N., Landin-Romero R., Matallana D., Slachevsky A., Torralva T., Chialvo D., Kumfor F., García A.M., Manes F., Hodges J.R. and Ibanez A.,  Hum. Brain Mapp., 2017, 38(8): 3804-3822.
Dementia in Latin America: Epidemiological Evidence and Implications for Public Policy. Custodio N., Wheelock A., Thumala D. and Slachevsky A.,  Front. Aging Neurosci., 2017, 9: 221.
Using game authoring platforms to develop screen-based simulated functional assessments in persons with executive dysfunction following traumatic brain injury. Martínez-Pernía D., Núñez-Huasaf J., Del Blanco Á., Ruiz-Tagle A., Velásquez J., Gomez M., Robert Blesius C., Ibañez A., Fernández-Manjón B. and Slachevsky A.,  J. Biomed. Inform., 2017, 74: 71-84.
Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway. González A.E., Muñoz V.C., Cavieres V.A., Bustamante H.A., Cornejo V.H., Januário Y.C., González I., Hetz C., daSilva L.L., Rojas-Fernández A., Hay R.T., Mardones G.A. and Burgos P.V.,  FASEB J., 2017, 31(6): 2446-2459.
Endoplasmic reticulum proteostasis impairment in aging. Martínez G., Duran-Aniotz C., Cabral-Miranda F., Vivar J.P. and Hetz C.,  Aging Cell., 2017, 16(4): 615-623.
Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372. Coddou C., Sandoval R., Castro P., Lazcano P., Hevia M.J., Rokic M., Hall B., Terse A., Gonzalez-Billault C., Kulkarni A.B., Stojilkovic S.S. and Utreras E.,  Pain., 2017 .
Aging and health policies in Chile: new agendas for research. Thumala D., Kennedy B.K., Calvo E., Gonzalez-Billault C., Zitko P., Lillo P., Villagra R., Ibáñez A., Assar R., Andrade M. and Slachevsky A.,  J. Health Systems & Reform, 2017 .
Enhanced Working Memory Binding by Direct Electrical Stimulation of the Parietal Cortex. Birba A., Hesse E., Sedeño L., Mikulan E.P., García M.D.C., Ávalos J., Adol F., Legaz A., Bekinschtein T.A., Zimerman M., Parra M., García A.M. and Ibáñez A.,  Front Aging Neurosci., 2017, 9: 178.
Brain information sharing during visual short-term memory binding yields a memory biomarker for familial Alzheimer’s disease. Parra M.A., Mikulan E., Trujillo N., Sala S.D., Lopera F., Manes F., Starr J. and Ibanez A.,  Curr Alzheimer Res., 2017 .
Towards affordable biomarkers of frontotemporal dementia: A classification study via network’s information sharing. Dottori M., Sedeño L., Martorell Caro M., Alifano F., Hesse E., Mikulan E., García A.M., Ruiz-Tagle A., Lillo P., Slachevsky A., Serrano C., Fraiman D. and Ibanez A.,  Sci. Rep., 2017, 7(1): 3822.
Gastrulation in an annual killish: Molecular and cellular events during germ layer formation in Austrolebias. Pereiro L., Loosli F., Fernández J., Härtel S., Wittbrodt J. and Concha M.,  Dev. Dyn., 2017 .
Changes in neural circuitry associated with depression at pre-clinical, pre-motor and early motor phases of Parkinson’s disease. Borgonovo J., Allende-Castro C., Laliena A., Guerrero N., Silva H. and Concha M.L.,  Parkinsonism Relat Disord., 2017, 35: 17-24.
ER stress and the unfolded protein response in neurodegeneration. Hetz C. and Saxena S.,  Nature Rev Neurol., 2017, 13(8): 477-491.
Fine-Tuning ER Stress Signal Transducers to Treat Amyotrophic Lateral Sclerosis. Medinas D., González J.V., Falcon P. and Hetz C.,  Front Mol Neurosci., 2017, 10( 216): .
The Mitochondrial Complex(I)ty of Cancer. Urra F.A., Muñoz F., Lovy A. and Cárdenas C.,  Front Oncol., 2017, 7: 118.
BCL-2 family: integrating stress responses at the ER to control cell demise. Mercado G. and Hetz C.,  Cell Death Dier., 2017, 24(9): 1478-1487.
Drug repurposing to target proteostasis and prevent neurodegeneration: accelerating translational efforts. Mercado G. and Hetz C.,  Brain, 2017, 140(6): 1544-1547.
Cdk5 Regulation of the GRAB-Mediated Rab8-Rab11 Cascade in Axon Outgrowth. Furusawa K., Asada A., Urrutia P., Gonzalez-Billault C., Fukuda M. and Hisanaga S.I., J. Neurosci., 2017, 37(4): 790-806.
Identity of the Purkinje cell cytoplasmic antibody type 2 autoantibody antigen is finally revealed. Gonzalez-Billault C., Ann Neurol., 2017, 81(5): 618-619.
Microtubule-regulating proteins and cAMP-dependent signaling in neuroblastoma differentiation. Muñoz-Llancao P., de Gregorio C., Las Heras M., Meinohl C., Noorman K., Boddeke E., Cheng X., Lezoualc’h F., Schmidt M. and Gonzalez-Billault C., Cytoskeleton, 2017, 74(3): 143-158.
Extra-embryonic tissue spreading directs early embryo morphogenesis in killifish. Reig G., Cerda M., Sepúlveda N., Flores D., Castañeda V., Tada M., Härtel S. and Concha M.L., Nature Communications, 2017, 8.
A core avenue for transcultural research on dementia: on the cross-linguistic generalization of language-related effects in Alzheimer’s disease and Parkinson’s disease. Calvo N., Ibáñez A., Muñoz E. and García A.M., Int. J. Geriatr. Psychiatry., 2017.
Action-semantic and syntactic deficits in subjects at risk for Huntington’s disease. García A.M., Bocanegra Y., Herrera E., Pino M., Muñoz E., Sedeño L. and Ibáñez A., Journal of Neuropsychology, 2017.
Non-Invasive Brain Stimulation: A New Strategy in Mild Cognitive Impairment?. Birba A., Ibáñez A., Sedeño L., Ferrari J., García A.M., and Zimerman M., Front. Aging Neurosci., 2017, 9(16): 1-13.
Brain structural correlates of executive and social cognition profiles in behavioral variant frontotemporal dementia and elderly bipolar disorder. Baeza S., Pinasco C., Roca M., Ferrari J., Couto B., García-Cordero I., Ibáñez A., Cruz F., Reyes P., Matallana D., Manes F., Cetcovich M. and Torralva T., Neuropsychologia, 2017.
Language Deficits as a Preclinical Window into Parkinson’s Disease: Evidence from Asymptomatic Parkin and Dardarin Mutation Carriers. García A.M., Sedeño L., Trujillo N., Bocanegra Y., Gomez D., Pineda D., Villegas A., Muñoz E., Arias W. and Ibáñez A., J. Int. Neuropsych. Soc., 2017, 23: 150–158.
Unspeakable motion: Selective action-verb impairments in Parkinson’s disease patients without mild cognitive impairment. Bocanegra Y., García A.M., Lopera F., Pineda D., Baena A., Ospina P., Alzate D., Buriticá O., Moreno L., Ibáñez A. and Cuetos F., Brain & Language, 2017, 168: 37–46.
A Lesion-Proof Brain? Multidimensional Sensorimotor, Cognitive, and Socio-Affective Preservation Despite Extensive Damage in a Stroke Patient. García A.M., Sedeño L., Herrera Murcia E., Couto B. and Ibáñez A., Front. Aging Neurosci., 2017, 8(335): 1-10.
The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo. Park K.W., Eun Kim G., Morales R., Moda F., Moreno-Gonzalez I., Concha-Marambio L., Lee A.S., Hetz C. and Soto C., Sci. Rep., 2017, 7: 44723.
IRE1 signaling exacerbates Alzheimer’s disease pathogenesis. Durán-Aniotz C., Cornejo V.H., Espinoza S., Ardiles Á.O., Medinas D.B., Salazar C., Foley A., Gajardo I., Thielen P., Iwawaki T., Scheper W., Soto C., Palacios A.G., Hoozemans J.J. and Hetz C., Acta Neuropathol., 2017.
Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and Mitochondrial Function in MIN6 Cells. Cataldo L., Mizgier M.L., Bravo R., Jaña F., Cárdenas C., Llanos P., Olmos P.R., Galgani J.E., Santos J.L. and Cortés V.A., PLOS One, 2017, 12(1): e0170213.
The Paraguayan Rhinella toad venom: Implications in the traditional medicine and proliferation of breast cancer cells. Schmeda-Hirschmann G., Gomez C.V., de Arias A.R., Burgos-Edwards A., Alfonso J., Rolon M., Brusquetti F., Netto F., Urra FA., Cárdenas C., J. Ethnopharmacol., 2017, 199: 106–118.
Diabetic concentrations of Metformin inhibit platelet-mediated ovarian cancer cell progression. Erices R., Cubillos S., Aravena R., Santoro F., Marquez M., Orellana R., Ramírez C., González P., Fuenzalida P., Bravo M.L., Oliva B., Kato S., Ibañez C., Brañes J., Bravo E., Alonso C., García K., Arab C., Torres V.A., Godoy A., Pereira J., Bustos G., Cárdenas C., Cuello M.A. and Owen G.I., Oncotarget, 2017, 8: 20865-20880.
Prion Function and Pathophysiology in Non-Mammalian ModelsGuerrero N., Meynard M., Borgonovo J., Palma K., Concha M. and Hetz C., Curr. Mol. Med., 2017, 17.
The unfolded protein response (UPR): at the intersection between ER function and mitochondrial bioenergetics. Pihán P., Carreras-Sureda A. and Hetz C., Front. Oncol., 2017, 7: 55.
A molecular reporter for monitoring autophagy flux in the nervous system. Castillo K., Valenzuela V., Oñate M. and Hetz C., Methods Enzymol. 2017;588:109-131.
Endoplasmic reticulum proteostasis in glioblastoma-From molecular mechanisms to therapeutic perspectives. Obacz J., Avril T., Le Reste P.J., Urra H., Quillien V., Hetz C. and Chevet E., Sci Signal., 2017, 10(470): eaal2323.
Hepcidin attenuates amyloid beta-induced inflammatory and pro-oxidant responses in astrocytes and microglia. Urrutia P.J., Hirsch E.C., González-Billault C. and Núñez M.T., J Neurochem., 2017.
The cost of dementia in an unequal country: The case of Chile. Hojman D.A., Duarte F., Ruiz-Tagle J., Budnich M., Delgado C. and Slachevsky A., PLoS One, 2017, 12(3): e0172204.
2016
Behavioral and Electrophysiological Correlates of Memory Binding Deficits in Patients at Different Risk Levels for Alzheimer’s Disease. Pietto M., Parra M.A., Trujillo N., Flores F., García A.M., Bustin J., Richly P., Manes F., Lopera F., Ibáñez A. and Baez S., J. Alzheimers Dis., 2016, 53(4): 1325-1340.
Your misery is no longer my pleasure: Reduced schadenfreude in Huntington’s disease families. Baez S., Santamaría-García H., Orozco J., Fittipaldi S., García A.M., Pino M. and Ibáñez A., Cortex, 2016, 83: 78-85.
How language flows when movements don’t: An automated analysis of spontaneous discourse in Parkinson’s disease. García A.M., Carrillo F., Orozco-Arroyave J.R., Trujillo N., Vargas Bonilla J.F., Fittipaldi S., Adolfi F., Nöth E., Sigman M., Fernández Slezak D., Ibáñez A. and Cecchi G.A., Brain Lang., 2016, 162: 19-28.
Language Deficits as a Preclinical Window into Parkinson’s Disease: Evidence from Asymptomatic Parkin and Dardarin Mutation Carriers. García A.M., Sedeño L., Trujillo N., Bocanegra Y., Gomez D., Pineda D., Villegas A., Muñoz E., Arias W. and Ibáñez A., J. Int. Neuropsychol. Soc., 2017, 23(2): 150-158.
Social neuroscience: Undoing the schism between neurology and psychiatry. Ibanez A., Garcia A., Esteves S., Yoris A., Edinson M., Reynaldo L., Pietto M., Adolfi F. and Manes F., Soc. Neurosci., 2016: 1-39.
The road less traveled: Alternative pathways for action-verb processing in Parkinson’s disease. Abrevaya S., Sedeño L., Fitipaldia S., Pineda D., Lopera F., Buritica O., Villegas A., Bustamante C., Gomez D., Trujillo N., Pautassi R., Ibáñez A. and García A.M., J. Alzheimers Dis.,  2017, 55(4): 1429-1435.
The cerebellum and embodied semantics: Evidence from a case of genetic ataxia due to STUB1 mutations. García A.M., Abrevaya S., Kozono G., García-Cordero I., Córdoba M., Kauffman M.A., Pautassi R., Muñoz E., Sedeño L. and Ibáñez A., J. Med. Genet., 2017, 54(2): 114-124.
Dementia in Latin America: An emergent silent tsunami. Baez S. and Ibanez A., Front. Aging Neurosci., 2016, 8: 253.
Nodal signalling and asymmetry of the nervous system. Signore I.A., Palma K. and Concha M.L., Philos. Trans. R Soc. Lond. B Biol. Sci., 2016, 371(1710): 20150401.
Directional asymmetry in the volume of the human habenula. Ahumada-Galleguillos P., Lemus C.G., Diaz E., Osorio-Reich M., Härtel S. and Concha M.L., Brain Struct. Funct., 2017, 222(2): 1087-1092.
Heterochrony and Morphological Variation of Epithalamic Asymmetry. Signore I.A. and Concha M.L.J. Exp. Zool. B Mol. Dev. Evol., 2016, 328(1-2): 157-164.
ER chaperones in neurodegenerative disease: Folding and beyond. Garcia-Huerta P., Bargsted L., Rivas A., Matus S. and Vidal R., Brain Res., 2016, 1648(Pt B): 580-587.
Targeting ER acetylation to restore proteostasis in Alzheimer’s disease. Duran-Aniotz C., Cornejo V. and Hetz C., Brain, 2016, 139(Pt 3): 650-652.
Glucose metabolism: A Sweet relief of Alzheimer´s disease. Duran-Aniotz C. and Hetz C., Curr Biol., 2016, 26(17): R806-809.
Commentary: XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity. Martínez G., Duran-Aniotz C., Cabral-Miranda F. and Hetz C., Front. Aging Neurosci., 2016, 8: 182.
ERp57 in neurodegeneration and regeneration. Bargsted L., Hetz C. and Matus S., Neural Regen. Res., 2016, 11(2): 232-233.
Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbations. Mollereau B., Roussel B.D., Chevet E., Sedru M., Van den Brink D., Bailly-Maitre B., Palladino F., Medinas D.B.,Domingos P.M., Hunot S., Chandran S., Rzechorzek N.M., Birman S., Baron T., Vivien D., Duarte C.B., Ryoo H.D.., Crowder C.M., Urano F., Steller H., Kroemer G., Ciechanover A., Calabrese E., Kaufman R.J. and Hetz C., Brain Res., 2016, 1648(Pt B): 603-616.
Gene therapy to target ER stress in brain diseases. Valenzuela V., Martínez G., Duran-Aniotz C. and Hetz C., Brain Res., 2016, 1648(Pt B): 561-570.
Guidelines for the use and interpretation of assays for monitoring autophagy (2nd edition). Klionsky et al and Hetz C., Autophagy, 2016, 12(1): 1-222.
ERp57 as a novel cellular factor controlling Prion biosynthesis: Therapeutic potential of protein disulfide isomerases. Sepulveda M., Rozas P., Hetz C. and Medinas D., Prion, 2016, 10(1): 50-56.
The intersection between growth factors, autophagy and ER stress: A new target to treat neurodegenerative diseases?. Garcia-Huerta P., Troncoso-Escudero P., Jerez C., Hetz C. and Vidal R.L., Brain Res. 2016 Oct 15;1649(Pt B):173-180.
The ER proteostasis network in ALS: explaining the differential motoneuron vulnerability. Rozas P., Bargsted L., Martínez F., Hetz C. and Medinas D.B., Neurosci. Lett., 2017, 636: 9-15.
Peroxisomes Get Loud: A Redox Antidote to Hearing Loss. Mardones P. and Hetz C., Cell., 2015, 163(4): 790-791.
Divergent roles of ER stress in neurodegeneration and brain disorders. Hetz C. and Saxena S.Brain Res., 2016, 1648:527-529.
Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport. Mardones P., Rubinztein D. and Hetz C., Sci. Signal., 2016, 9(416): fs2.
Proteostasis control by the unfolded protein response. Hetz C., Chevet E., and Oakes S., Nature Cell Biology 2015, 17(7): 829–838.
ER stress and the hallmarks of cancer. Urra H., Dufey E., Avril T., Chevet E. and Hetz C., Trends in Cancer, 2016, 2(5): 252-262.
PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response. Gupta A., Mosaraf Hossain M., Read D.E., Hetz C., Samali A. and Gupta S., Scientific Reports, 2015, 5: 18304.
Creutzfeldt-Jakob disease. Report of one case. Ramírez M., Gallardo A., Cornejo A., Vidal A., Ramírez D., Medinas D., Hetz C., Bustamante G. and Pasquali R., Rev. Med. Chile, 2016, 144: 6.
NFκB is a central regulator of protein quality control in response to protein aggregation stresses via autophagy modulation. Nivon M., Fort L., Muller P., Richet E., Simon S., Guey B., Fournier M., Arrigo A.P., Hetz C., Atkin J.D. and Kretz-Remy C., Mol. Biol. Cell., 2016, 27(11): 1712-1727.
Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anti-cancer agent. Xiang M., Kim H., Ho V.T., Walker S.R., Bar-Natan M., Anahtar M., Liu S., Toniolo P.A., Kroll Y., Jones N., Giaccone Z.T., Heppler L.N., Ye D.Q., Marineau J.J., Shaw D., Bradner J.E., Blonquist T., Neuberg D., Hetz C., Stone R.M., Soiffer R.J. and Frank D.A., Blood, 2016, 128: 1845-1853.
ALS-linked Protein Disulfide Isomerase Variants cause motor dysfunction. Woehlbier U., Colombo A., Saaranen M., Pérez V., Ojeda J., Bustos F., Andreu C., Torres M., Valenzuela V., Medinas D., Rozas P., Vidal R., Lopez-Gonzalez R., Salameh J., Fernandez-Collemann S., Muñoz N., Matus S., Armisen R., Sagredo A., Palma K., Irrazabal T., Gonzalez-Perez P., Campero M., Gao F, Henny P., van Zundert B., Ruddock L., Concha M., Henriquez J., Brown R.H. and Hetz C., EMBO J., 2016, 35(8): 845-865.
Regulation of Memory Formation by the Transcription Factor XBP1. Martínez G., Vidal R.L., Mardones P., Serrano F.G., Ardiles A.O., Wirth C., Valdés P., Thielen P., Schneider B.L., Kerr B., Valdés J.L., Palacios A.G., Inestrosa N.C., Glimcher L.H. and Hetz C., Cell Rep., 2016, 14(6): 1382-1394.
Neuropsychiatric Characteristics of Alzheimer’s Disease and the Behavioral Variant of Frontotemporal Dementia. Muñoz-Neira C., Slachevsky A. and López Oscar L., JSM Alzheimer’s Dis Related Dementia, 2016, 3(1): 1023.
Cuidados paliativos en personas con demencia severa: reflexiones y desafíos. Demencia severa y cuidados de fin de vida. Slachevsky A., Abusleme Lama M.T. y Arenas Massa A., Rev. Med. Chile 2016, 144: 94-101.
Sé y puedo? Toma de decisión y consentimiento informado en los trastornos demenciantes: Dilemas diagnósticos y jurídicos en Chile. Arenas Massa A. y Slachevsky A., Rev. Med. Chile 2016.
Comparison of the psychometric properties of the “Word” and “Picture” Versions of the Free and Cued Selective Reminding Test in a Spanish-speaking cohort of patients with mild Alzheimer’s disease and cognitively healthy controls. Delgado C., Muñoz-Neira C., Soto A., Martinez M., Henriquez F., Flores P. and Slachevsky A., Arch. Clin. Neuropsychol., 2016, 31(2): 165-175.
First symptoms and neurocognitive correlates of behavioral variant frontotemporal dementia. Santamaría-García H., Reyes P., Baéz S., García A., Martinez A., Santacruz J.M.,  Slachevsky A., Sigman M., Matallana D. and Ibañez A., J. Alzheimers Dis., 2016, 54(3): 957-970.
Your perspective and my benefit: multiple lesion models of self-other integration strategies during social bargaining. Melloni M., Billete P., Baez S., Hesse E., de la Fuente L., Forno G., Birba A., García Cordero I., Serrano C., Plastino A., Slachevsky A., Huepe D.,  Sigman M., Manes F., García A.M., Sedeño L. and  Ibáñez A., Brain, 2016, 139(11): 3022-3040.
Geographical variation in dementia mortality in Italy, New Zealand, and Chile: the impact of latitude, vitamin D, and air pollution.  Russ T.C., Murianni L., Icaza G., Slachevsky A. and Starr J.M., Dement. Geriatr. Cogn. Disord., 2016, 42(1-2): 31-41.
So close yet so far: executive contribution to memory processing in behavioural variant frontotemporal dementia. Bertoux M., Ramanan S., Slachevsky A., Wong S., Henriquez F., Musa G., Dubois B., Bottlaender M., Sarazin M. and Hornberger M., J. Alzheimers Dis. 2016 Oct 4;54(3):1005-1014.
Tau Platelets correlates with regional brain atrophy in patients with Alzheimer’s disease. Slachevsky A., Guzmán-Martínez L., Delgado C., Reyes P., Farías G.A., Muñoz C., Bravo E., Farías M., Flores P., Garrido C., Becker J.T., López O.L. and Maccioni R.B., J. Alzheimers Dis., 2017, 55(4): 1595-1603.
Origin of axonal proteins: Is the axon-schwann cell unit a functional syncytium?López-Leal R., Alvarez J. and Court F.A., Cytoskeleton, 2016, 73(10): 629–639.
Schwann Cell and Axon: An Interlaced Unit-From Action Potential to Phenotype Expression. Court F.A. and Alvarez J., Adv. Exp. Med. Biol., 2016, 949: 183-201.
Bursting the unfolded protein response accelerates axonal regeneration. Oñate M., Court F.A. and Hetz C., Neural Regen. Res., 2016, 11(6): 892–893.
Injury to the nervous system: A look into the ER. Valenzuela V., Oñate M., Hetz C. and Court F.A., Brain Res., 2016, 1648(Pt B): 617-625.
Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury. Calvo M., Richards N., Schmid A.B., Barroso A., Zhu L., Ivulic D., Zhu N., Anwandter P., Bhat M.A., Court F.A., McMahon S.B. and Bennett D.LH., eLife, 2016, 5: e12661.
Schwann Cell Exosomes Mediate Neuron–Glia Communication and Enhance Axonal Regeneration. Lopez-Leal R. and Court F.A., Cell. Mol. Neurobiol., 2016, 36(3):429-436.
Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury. Oñate M., Catenaccio A., Martínez G., Armentano D., Parsons G., Kerr B., Hetz C. and Court F.A., Sci. Rep., 6: 21709.
Axons provide the secretory machinery for trafficking of voltage-gated sodium channels in peripheral nerve. González C., Cánovas J., Fresno J., Couve E., Court F.A. and Couve A., Proc. Natl. Acad. Sci., 2016, 113(7): 1823-1828.
Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria. Cárdenas C., Muller M., McNeal A., Lovy A., Jaňa F., Bustos G., Smith N., Molgo J., Diehl A., Ridky T.W. and Foskett J.K., Cell Rep., 2016, 14(10): 2313–2324.
Antiproliferative activity and chemical composition of the venom from the Amazonian toad Rhinella marina (Anura: Bufonidae). Schmeda-Hirschmann G., Quispe C., Arana G.V., Theoduloz C., Urra F.A. and Cárdenas C., Toxicon, 2016, 121: 119-129.
Aminochrome induces dopaminergic neuronal dysfunction: a new animal model for Parkinson’s disease. Herrera A., Muñoz P., Paris I., Díaz-Veliz G., Mora S., Inzunza J., Hultenby K., Cardenas C., Jaña F., Raisman-Vozari R., Gysling K., Abarca J., Steinbusch H.W. and Segura-Aguilar J., Cell. Mol. Life Sci., 2016, 73(18): 3583–3597.
InsP3R, the Calcium Whisperer: Maintaining Mitochondrial Function in Cancer. Lovy, A. Foskett, J.K. and Cardenas C., Molecular & Cellular Oncology, 2016, 3(4): e1185563.
Rab GTPase signaling in neurite outgrowth and axon specification. Villarroel-Campos D., Bronfman F.C. and Gonzalez-Billault C., Cytoskeleton, 2016, 73(9): 498-507.
Cellular and molecular mechanisms regulating neuronal growth by brain-derived neurotrophic factor. Gonzalez A., Moya-Alvarado G., Gonzalez-Billault C. and Bronfman F.C., Cytoskeleton, 2016, 73(10): 612-628.
Ligand-mediated Galectin-1 endocytosis prevents intraneural H2O2 production promoting F-actin dynamics reactivation and axonal re-growth. Quintá H.R., Wilson C., Blidner A.G., González-Billault C., Pasquini L.A., Rabinovich G.A. and Pasquini J.M., Exp Neurol., 2016, 283(Pt A): 165-178.
Rab35 functions in axon elongation are regulated by p53-related protein kinase in a mechanis that involves Rab35 protein degradation and the microtubule-associated protein 1B. Villarroel-Campos D., Henríquez D.R., Bodaleo F.J., Oguchi M.E., Bronfman F.C., Fukuda M. and Gonzalez-Billault C., J Neurosci., 2016, 36(27): 7298-7313.
Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology. Bodaleo F.J., Montenegro-Venegas C., Henríquez D.R., Court F.A. and Gonzalez-Billault C., Scientific Reports, 2016, 6: 30069.
The presynaptic microtubule cytoskeleton in physiological and pathological conditions: lessons from Drosophila Fragile X Syndrome and hereditary spastic paraplegias.  Bodaleo F.J. and Gonzalez-Billault C., Front. Mol. Neurosci., 2016, 9(60): 1-16.
CDK5 downregulation enhances synaptic plasticity. Posada-Duque R.A., Ramirez O., Härtel S., Inestrosa N.C., Bodaleo F., González-Billault C., Kirkwood A. and Cardona-Gómez G.P., Cell Mol Life Sci., 2017, 74(1): 153-172.
p120-catenin is necessary for neuroprotection induced by CDK5 silencing in models of Alzheimer’s disease. Uribe-Arias A., Posada-Duque R.A., González-Billault C., Villegas A., Lopera F. and Cardona-Gómez G.P., J Neurochem., 2016, 138(4): 624-639.
Actin filaments-a target for redox regulationWilson C., Terman J.R., González-Billault C. and Ahmed G., Cytoskeleton, 2016, 73(10): 577-595.
Dissecting the role of redox signaling in neuronal development. Bórquez D.A., Urrutia P.J., Wilson C., van Zundert B., Núñez M.T. and González-Billault C., J. Neurochem., 2016, 137: 506-517.
A Feed-Forward Mechanism Involving the NOX Complex and RyR-Mediated Ca2 Release During Axonal Specification. Wilson C., Munñoz-Palma E., HenríquezD.R., Palmisano I., Núñez M.T., Di Giovanni S. and González-Billault C., The Journal of Neuroscience, 2016, 36(43):11107–11119.
Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia. Baez S., Morales J.P., Slachevsky A., Torralva T., Matus C., Manes F., Ibañez A., Cortex, 2016, 75: 20-32.
Integration of Intention and Outcome for Moral Judgment in Frontotemporal Dementia: Brain Structural Signatures. Baez S., Kanske P., Matallana D., Reyes P., Slaschevsky A., Matus C., Vigliecca N.S., Torralva T., Manes F. and Ibañez A., Neurodegener Dis., 2016, 16: 206–217. 
The Social Context Network Model in Psychiatric and Neurological Diseases. Baez S., García A.M. and Ibáñez A.,  Curr Top Behav Neurosci., 2017, 30: 379-396.
Feeling, learning from, and being aware of inner states: Interoceptive dimensions in neurodegeneration and stroke. García-Cordero I., Sedeño L., de la Fuente L. , Slachevsky A., Forno G., Klein F., Lillo P., Ferrari J., Rodriguez C., Bustin J., Torralva T., Baez S., Yoris A., Esteves S., Melloni M., Salamone P., Huepe D., Manes F., García A. and Ibañez A., Phil. Trans. R. Soc. B, 2016, 371(1708).